Endocrine Abstracts

Glycogen storage disease (GSD) type 1 is an autosomal recessive disorder in which there is problem in glucose 6 phosphatase system. Glucose-6-phosphate transport protein deficiency is found in GSD type 1b. There is disorder in glucose metabolism, lack of glucose production in liver. Hypoglycemia, seizures, lactic acidosis, hyperuricemia and hyperlipidemia are some of the components. Affected people may also have short stature, pancytopenia and inflammatory bowel disease. Our a...

Introduction: Previous reports have shown that subjects with insulin resistance have increased thyroid volume and nodule prevalence. We investigated the effects of metformin on thyroid volume and nodule size.Methods: This prospective data were gathered on newly diagnosed subjects with insulin resistance (n=100, 68 female, 32 male) between August 2008 and May 2010. Measurements of thyroid hormones and thyroid ultrasonography was performed in all ...

There are limited data inquiring the relationship between somatostatin analogues and insulin sensitivity among acromegalic cases. This study was conducted to evaluate short-term effects of lanreotide autogel (LA), administered every 28 days by deep subcutaneous injection, on insulin sensitivity among acromegalic patients with pituitary tumors. Before and following six months of LA treatment, insulin resistance and beta-cell function were calculated by using homeostasis model a...

Pain is one of the few drawbacks of fine-needle aspiration biopsy (FNAB) in patients with nodular thyroid disease (NTD). Lidocaine/prilocaine cream, an eutectic mixture of local anesthetics (EMLA), is a frequently used topical anesthetic. Despite its well-documented efficacy for the relief of pain associated with other cutaneous procedures that involve needle insertion, the analgesic role of EMLA has not been previously reported in patients with NTD who are undergoing FNAB. Th...

Objective: Amiodarone-induced thyrotoxicosis (AIT) is usually classified into 2 types (type 1, in which a high iodine content triggers the autonomous production of thyroid hormone; and type 2, in which destructive thyroiditis causes the release of preformed thyroid hormone). A mixed form of AIT has also been also described. AIT is a difficult management problem that sometimes requires ablative thyroid therapy. The use of radioactive iodine (RAI) therapy in patients with type 1...